View abstract. View abstract. Kidney Int 2003;64:534-43. . Results 12 weeks following cessation of 8 weeks' supervised use. 2009;41(7):559-562. View abstract. View abstract. A., Korotkova, T. A., Toroptsova, N. V., Smirnov, A. V., Demin, N. V., Rodionova, S. S., Buklemeshev, IuV, and Shumskii, A. Information from this source is evidence-based and objective, and without commercial influence. View abstract. It has been licensed for sale in the UK and elsewhere in Europe for treatment of osteoporosis in postmenopausal women. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. Reginster, J. Y., Seeman, E., De Vernejoul, M. C., Adami, S., Compston, J., Phenekos, C., Devogelaer, J. P., Curiel, M. D., Sawicki, A., Goemaere, S., Sorensen, O. H., Felsenberg, D., and Meunier, P. J. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. View abstract. Human biokinetics of strontium--part II: Final data evaluation of intestinal absorption and urinary excretion of strontium in human subjects after stable tracer administration. View abstract. [No authors listed]. Calcif Tissue Int 2000;67:122-7. Uchida, A., Wakano, Y., Fukuyama, O., Miki, T., Iwayama, Y., and Okada, H. Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. J Clin Endocrinol Metab. 2010;21(12):1993-2002. View abstract. Some people say this supplement improves bone health, but its important to think about its benefits and risks before you decide to take it. J Endod 2002;28:34-5. N.Engl.J.Med. A consideration of the possible causes of dental hypersensitivity: treatment by a strontium-ion dentifrice. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9. Stable strontiums atomic symbol is Sr, its atomic number is 38 and its atomic weight is 87.62. Ringe, J. D. and Doherty, J. G. Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat. Most people who take strontium citrate report their fractures STOP. 5-10-2001;344(19):1434-1441. Type: Natural Calcium & Magnesium Supplement. According to Cancer Research UK, If there are cancer cells in more than one area of bone, radioactive strontium can work well to treat those areas and reduce pain. (11). 1972;43(6):367-372. Osteoporos Int. Any feedback to help me through this maze will be highly appreciated. View abstract. A new desensitizing dentifrice: preliminary report. N.Engl.J.Med. View abstract. Please note the date of the last review on all articles. Description Pure Encapsulations' Strontium capsules provide one of the many trace minerals essential to bone health. Relationship between bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. Maheu E, Mazieres B, Valat JP, et al. Olson, B. L., McDonald, J. L., Jr., and Stookey, G. K. The effect of strontium and fluoride upon in vitro plaque and rat caries. It is a rarecarbonate mineraland one of only a few strontium minerals. My bone density has shown some improvement and no further decline. Prostate cancer. Physio Flex Pro - Editor's Choice. Acta Derm Venereol. Spector, T. D., Conaghan, P. G., Buckland-Wright, J. C., Garnero, P., Cline, G. A., Beary, J. F., Valent, D. J., and Meyer, J. M. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. These forms are different from the ranelate compound and there have been no studies showing that they are safe or effective. Review of clinical studies. View abstract. Strontium can be found in supplement form online and in health stores. Hernandez, F., Mohammed, C., Shannon, I., Volpe, A., and King, W. Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices. Although Sr-89 is mostly used when there are several painful metastatic sites, its application in earlier stages of the disease is beneficial, and it may decrease progression and the need for external radiotherapy. View abstract. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. View abstract. Gedalia, I., Brayer, L., Kalter, N., Richter, M., and Stabholz, A. It is an alkaline earth metalmost similar to barium and calcium. View abstract. View abstract. Strontium, which is a trace element found in seawater and soil, has a chemical similarity to calcium and can replace calcium in the bone. Blake, G. M., Zivanovic, M. A., McEwan, A. J., and Ackery, D. M. Sr-89 therapy: strontium kinetics in disseminated carcinoma of the prostate. N.Engl.J.Med. Good luck to all of you. (21). Sairanen S, Karkkainen M, Tahtela R, et al. View abstract. Cochrane Database Syst Rev 2006;(4):CD005326. View abstract. Proc.R.Soc.Lond B Biol.Sci. WebMD does not provide medical advice, diagnosis or treatment. View abstract. Radiother Oncol 1994;31:33-40. Harris, S. T., Watts, N. B., Genant, H. K., McKeever, C. D., Hangartner, T., Keller, M., Chesnut, C. H., III, Brown, J., Eriksen, E. F., Hoseyni, M. S., Axelrod, D. W., and Miller, P. D. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Most calcium supplements are big and difficult to swallow. Osteoporos.Int. 9-25-2006;166(17):1899-1906. Rev Rhum Engl Ed 1997;64(12):825-834. 2002;13(12):925-931. Metastron prescribing information. Liberman, U. Scientists havent tested these supplements much, so theres not enough research to know if they fight osteoporosis. JAMA 12-23-1998;280(24):2077-2082. This is the newest bone-building medication to treat osteoporosis. Fidelix, T. S., Soares, B. G., and Trevisani, V. F. Diacerein for osteoarthritis. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. This could cause the body to have too much strontium and potentially cause side effects. Les Laboratoires Servier, 2006. Strontium ranelate has never been approved in the U.S. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. Reichenbach, S., Blank, S., Rutjes, A. W., Shang, A., King, E. A., Dieppe, P. A., Juni, P., and Trelle, S. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. 2005;16(10):1291-1298. View abstract. A typical dosage of strontium in over-the-counter supplements is 680 mg a day. View abstract. 2013 Feb;72(2):179-86. doi: 10.1136/annrheumdis-2012-202231. If youre not into chemistry, then those scientific facts probably dont mean that much to you. 2006;45(3):179-185. 2000;57(3):1107-1114. View abstract. Strontium ranelate is comprised of 27.8% strontium and 72.2% ranelic acid. Diagnosis and Management. View abstract. [1] PRAC recommends suspending use of Protelos/Osseor. 2014. Ozgur S, Sumer H, Kocoglu G. Rickets and soil strontium. 2010;21(2):42-48. [Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. View abstract. View abstract. A common therapeutic dose you will often seen recommended for boosting bone health is 680 milligrams per day. All Rights Reserved. View abstract. View abstract. It boils at 2,520 degrees F (1,382 degrees C) and melts at1,431 degrees F (777 degrees C). 2006;34(8):608-613. Hello @bonelady. [RETRACTED]. Is reclast a safe treatment for osteoporosis I have not done anything so far except strontium citrate? 2010;21(4):667-677. This decreases the amount of quinolones that can be absorbed. View abstract. O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Posted: 09/28/19;Revised: 09/25/20. View abstract. 5 Reasons to Add Lamb Meat to Your Diet. 1992;63(1):7-12. 2007;357:nihpa40967. Wang, C. T., Lin, J., Chang, C. J., Lin, Y. T., and Hou, S. M. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. If you want to take a strontium supplement, it is recommended to ask your doctor first. Strontium has a long list of undesirable side-effects, commonly ranging from nausea to skin irritation, and less often (fortunately), blood clots and fainting. I wont name names, but some of the most well-known toothpastes for sensitive teeth include strontium in their formulas. Strontium ranelate has risks though. Because strontium ranelate is a weak anti-resorptive agent and there are more effective osteoporosis agents in the United States and most countries, we do not use strontium ranelate in postmenopausal women with osteoporosis. CMAJ. (20). Rabenda, V. and Reginster, J. Y. 2011;22(8):2347-2355. 2008;67(12):1736-1738. It is also among the forms of Strontium supplements backed by studies regarding safety and efficiency. Effects of strontium ranelate on spinal osteoarthritis progression. Hughes, N., Mason, S., Jeffery, P., Welton, H., Tobin, M., O'Shea, C., and Browne, M. A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. Bruyere, O., Burlet, N., Delmas, P. D., Rizzoli, R., Cooper, C., and Reginster, J. Y. Scientific studies have shown that Sr may have positive effects on bone diseases like osteoporosis, bone cancer, prostate cancer, tooth sensitivity and tooth decay. Boivin, G., Farlay, D., Khebbab, M. T., Jaurand, X., Delmas, P. D., and Meunier, P. J. Faith123 may be able to answer a question or two of yours about the reclast infusion treatment and her experience with it. The treatment can sometimes cause anemia after a few weeks, so you need to have regular blood tests after the treatment. View abstract. Its also used to create that alerting red color in emergency flares. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Clin Chem 1999;45:1548-56. It is prescribed only for those who would otherwise have no other suitable treatment to reduce their risk of broken bones.[2]. Also, the FDA doesnt regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain. Osteoporos.Int. View abstract. Upset stomach and diarrhea are the most common side effects of magnesium oxide. Oosterhof GO, Roberts JT, de Reijke TM, et al. View abstract. You do not know what amounts your body is getting when you take these supplements. Oral Dis. Roque, I. Figuls, Martinez-Zapata, M. J., Scott-Brown, M., and Alonso-Coello, P. Radioisotopes for metastatic bone pain. 2-1-2001;344(5):333-340. Gutteridge DH, Robinson CJ, Joplin GF. Roux, C., Fechtenbaum, J., Kolta, S., Briot, K., and Girard, M. Mild prevalent and incident vertebral fractures are risk factors for new fractures. Delayed strontium absorption in post-menopausal osteoporosis and osteomalacia. Strontium may also influence other essential functions, including calcium absorption, bone formation & breakdown, and it restores alkaline pH to improve the health of skin, hair, and nails). 2011;165(3):469-476. Sr supplements are controversial and should be considered very carefully. Papoiu AD, Valdes-Rodriguez R, Nattkemper LA, Chan YH, Hahn GS, Yosipovitch G. A novel topical formulation containing strontium chloride significantly reduces the intensity and duration of cowhage-induced itch. This technology we use to assemble our list depends on a variety of factors, including but not limited to the following: Brand Value: Every brand of strontium citrate . Hip Intervention Program Study Group. Fracture Intervention Trial Research Group. Clin Sci 1968;34:351-63. Doctors arent sure exactly how it works, but it seems to help the body make more bone and keep the bone you have from breaking down. View abstract. JAMA 12-17-2003;290(23):3115-3121. Bianchi ML, Ardissino GL, Schmitt CP, et al. Hunter House, 2014. View abstract. Cancer that has spread to bone and causes pain. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. Doctors can prescribe it only for postmenopausal women and for men with severe osteoporosis who cant take other drugs. Best Joint Supplements In 2023: Knee Pain & Joint Support. View abstract. Previous research demonstrates that strontium ranelate can promote bone formation while decreasing vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis. I am fortunate to have no noticeable side effects. @kishanvasekar My girlfriend has osteoporosis and the Dr put her on high doses of Vit D-3 sunshine exercise especially weights ,swimming .She is doing good. Boron may be suitable for arthritis when taken in appropriate amounts. D'Haese PC, Couttenye MM, Lamberts LV, et al. Founded in 1999, ConsumerLab.com is a leading provider of consumer information and independent evaluations of products that affect health and nutrition. Ann Rheum Dis. The PRAC weighed the benefits of the medicine against the known risks and concluded that the balance was no longer favourable and recommended Protelos/Osseor be suspended until there are new data showing a favourable balance in a defined patient group.[1]. This family of meds give your natural bone production a chance to play catch-up by slowing or stopping resorption, when bones break down and release minerals such as calcium into your blood. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., Mautalen, C., Mesenbrink, P., Hu, H., Caminis, J., Tong, K., Rosario-Jansen, T., Krasnow, J., Hue, T. F., Sellmeyer, D., Eriksen, E. F., and Cummings, S. R. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. Arthritis Rheum 2007;56(7):2267-2277. (4a) In addition, strontianite is a mineral that comes from concentrations of strontium compounds, and there are several strontium compounds. Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss. View abstract. View abstract. View abstract. View abstract. The compound Strontium Citrate has CAS number 40182-75- and molecular formula C6H5O7Sr-. It has shown only a modest effect in preventing recurrent vertebral fractures. A meta-analysis of chondroitin sulfate in the treatment of osteoarthritis. We did it using a custom-created selection of algorithms that lets us manifest a top-10 list of the best available strontium citrate reviews currently available on the market. Quintessence.Int. The drug makes your bones stronger and lowers your chances of getting fractures. Rachitogenic activity of dietary strontium. Leeb BF, Schweitzer H, Montag K, Smolen JS. Scand J Rheumatol 2001;30(4):242-247. View abstract. The effect of fluoride and strontium application on dentin: in vivo and in vitro studies. 2012. Kaufman JM, Audran M, Bianchi G, et al. 1990;1(1):19-23. Strontium ranelate is associated with other harmful effects, including serious skin reactions, disturbances in thinking, seizures, liver inflammation, and reduced numbers of red blood cells. Lets talk about these answers and more. @faith123, recently posted about having a second reclast infusion recently here, https://connect.mayoclinic.org/discussion/reclast-infusion/. A., Mohr, D. N., Petterson, T. M., O'Fallon, W. M., and Melton, L. J., III. Erythritol: Is This Healthy Sweetener the Real Deal? 12-15-2007;57(8):1410-1418. [3] Bartl, R. & Bartl, C.The Osteoporosis Manual: Prevention. Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 1966;26:566-72. Although many people have never heard of it before, its a very interesting and somewhat controversial supplement. I'm glad you found us. Even though its not considered a nutrient, its known that the human body can absorb strontium and utilize it as it would calcium. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. Roux, C., Reginster, J. Y., Fechtenbaum, J., Kolta, S., Sawicki, A., Tulassay, Z., Luisetto, G., Padrino, J. M., Doyle, D., Prince, R., Fardellone, P., Sorensen, O. H., and Meunier, P. J. Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors. Hwang, J. S., Chen, J. F., Yang, T. S., Wu, D. J., Tsai, K. S., Ho, C., Wu, C. H., Su, S. L., Wang, C. J., and Tu, S. T. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis. View abstract. 1990;12(4):28-33. That means it may affect how strong your bones are. Zinc is crucial for various functions in the body, including: 1. View abstract. Some quinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin, moxifloxacin (Avelox), and others. IT was a 9 year nightmare until I started the strontium citrate. View abstract. Aging Clin.Exp.Res. Medina, J. M., Thomas, A., and Denegar, C. R. Knee osteoarthritis: should your patient opt for hyaluronic acid injection? Roux, C., Fechtenbaum, J., Kolta, S., Isaia, G., Andia, J. About 99% of the strontium in the human body is concentrated in the bones. It's also known to increase osteoprotegerin that serves as the decoy for the RANKL and slows the rate of bone resorption. Cottage cheese, 1% milk fat, 1 cup 138 mg per serving. It is also shown to positively impact the body's usage of testosterone, estrogen, and vitamin D. Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Baziotis N, Yakoumakis E, Zissimopoulos A, et al. A double blind, prospective, placebo-controlled study. J Natl Med Assoc 2002;94:706-11. Nonvertebral fracture benefit from oral ibandronate administered daily or with a unique drug-free interval: Results from a pivotal phase III study in postmenopausal osteoporosis (PMO). View abstract. 2008;23(3):433-438. View abstract. I will be contacting my urologist who I just began working with to let her know about Strontium. Have you discussed any treatments with your doctor or have they recommended anything to you? In the mean time I do have bone density scans to keep an eye on bone density. Health Phys 2004;86:193-6. Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures. Due to mixed research findings, its very important to speak with your doctor before supplementing with strontium to treat any health concern especially if you have Pagets disease of bone, kidney problems or any blood clotting disorders. A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. View abstract. Protelos European Summary of Product Characteristics. 2005;54(9):758-767. View abstract. View abstract. Bone 2009;45(3):460-465. Does anyone take Forteo ? Injecting myself daily. Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J. Y., Hodsman, A. 2006;21(7):1113-1120. Immune function. Because strontium and calcium have very similar molecular structures, the body treats them much the same. Afflitto, J., Schmid, R., Esposito, A., Toddywala, R., and Gaffar, A. Fluoride availability in human saliva after dentifrice use: correlation with anticaries effects in rats. (6), Strontium ranelate is a form that is sold as a prescription medication for osteoporosis and bone fractures in Europe and Australia. If you have questions on the differences between esomeprazole (Nexium) and esomeprazole strontium, or whether esomeprazole (Nexium) is an option for you, talk to your provider or pharmacist. (3). These side effects may be mild or severe. 2004;86-A(3):538-545. Rintelen, B., Neumann, K., and Leeb, B. F. A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis. View abstract. are clickable links to medically peer-reviewed studies. Glucosamine therapy for treating osteoarthritis. I'm glad you found us. This information may not fit your specific health circumstances. View abstract. Lyles, K. W., Colon-Emeric, C. S., Magaziner, J. S., Adachi, J. D., Pieper, C. F., Mautalen, C., Hyldstrup, L., Recknor, C., Nordsletten, L., Moore, K. A., Lavecchia, C., Zhang, J., Mesenbrink, P., Hodgson, P. K., Abrams, K., Orloff, J. J., Horowitz, Z., Eriksen, E. F., and Boonen, S. Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture. View abstract. Schrooten I, Elseviers MM, Lamberts LV, et al. 2008;58(6):1687-1695. Recker R, Stakkestad J Weber T et al. Addy, M., Mostafa, P., and Newcombe, R. G. Effect of plaque of five toothpastes used in the treatment of dentin hypersensitivity. 7-27-1965;162(989):458-472. Strontium controls the activity of OPG and RANKL; these are essential molecules that regulate the rates of bone resorption. It also appears that people with strontium in their local water supply seem to have decreased cavity risk. The naturally occurring form is made up of four stable isotopes: Sr-88 (82.6 percent), Sr-86 (9.9 percent), Sr-87 (7.0 percent), and Sr-84 (0.56 percent). Kishore A, Mehrotra KK, Saimbi CS. https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869, https://connect.mayoclinic.org/discussion/reclast-infusion/, https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/. 2006;54(10):3205-3211. 2002;17(3):449-454. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Sr should be used with caution for those with kidney disease and if you have advanced kidney disease, then strontium ranelate is not recommended at all. My teeth are really strong and it feels like my bones are too. McAlindon TE, LaValley MP, Gulin JP, Felson DT. View abstract. View abstract. Bellamy, N., Campbell, J., Robinson, V., Gee, T., Bourne, R., and Wells, G. Viscosupplementation for the treatment of osteoarthritis of the knee. Strontium citrate and strontium chloride are supplements and are not tested or regulated by the Food and Drug Administrations (FDA). View abstract. To measure the effectiveness of it, researchers measured bone mineral density in the neck, spine and hip as well as some biochemical bone markers. Strontium Citrate is one of the most common types of Strontium used in the dietary supplement field for bone health.